• Genetic control of neural crest formation, delamination and migration
• Molecular mechanisms of melanoma metastasis and drug resistance
• Modelling neurological diseases by cellular reprogramming

• Research Assistant Professor, Department of Biochemistry, The University of Hong Kong, Hong Kong
• Postdoctoral Fellow, Division of Developmental Neurobiology, The National Institute for Medical Research, London, United Kingdom
• Ph.D., Division of Genetics, The University of Nottingham, United Kingdom
• B.Sc. Hons (1^st), Department of Biochemistry, The Chinese University of Hong Kong, Hong Kong

The hallmark of embryonic development is complex genetic regulation of a single cell undergoing rapid growth, migration and differentiation into different cell types. Consequently, dysregulation of developmental program often leads to congenital diseases, tumor initiation and progression. The overarching goal of my research program is to use multiple experimental strategies including animal models, cellular, molecular, biochemical, imaging, organoid and omics approaches to understand genetic control of embryonic development that provide insight into the pathogenesis of tumorigenesis and congenital disorders for the development of therapeutic strategies. In this regard, we are interested in studying the genetic regulation of neural crest progenitors and their derivatives formation and how abnormal regulation of neural crest developmental program contributes to melanoma initiation, progression, and drug resistance. In addition, leveraging our expertise and knowledge, we have further expanded research interest in delineating the molecular mechanism of specific motor neuron degeneration caused by the loss of ubiquitously expressed survival motor neuron protein in spinal muscular atrophy.

Live cell imaging of RHOA biosensor showing a migrating neural crest cell with high RHOA activity in the cytoplasm of the cell rear relative to fluctuating RHOA activity in membrane protrusions at the leading front.

July 2025: Anson Wong and Venus Ho: BSc degree graduation; Hannah Xu: PhD graduation	July 2025: Rose leaving do

Lab photo

• PhD positions are available. Interested and eligible applicants are welcome to apply for the HK PhD Fellowship Scheme (https://cerg1.ugc.edu.hk/hkpfs/index.html) and HKU Presidential PhD Scholarship (https://gradsch.hku.hk/prospective_students/fees_scholarships_and_financial_support/hku_presidential_phd_scholar_programme). 

For further enquiries, please email me: mcheung9@hku.hk

Representative research articles:

1. Zheng ZF, Guo SS, Tam HY, Wang JK, Rao YX, Hui M-N, Cheung MPL, Leung AWL, Wong KKW, Sharma R, Liu JAJ and Cheung M*. Determination of Trunk Neural Crest Cell Fate and Susceptibility to Splicing Perturbation by the DLC1-SF3B1-PHF5A Splicing Complex. (2025) Nature Commun 16 (1): 6718. https://doi.org/10.1038/s41467-025-62003-6

2. Tan HQ, Miao XF, Luo RX, So J, Peng L, Zhu XX, Xhu L, Chan KM, Cheung M* and Chan SY*. TSPYL1 as a critical regulator of TGFb signaling through repression of TGFBR1 and TSPYL2. (2024) Adv Sci (Weinh) (in press) *(co-corresponding author) https://doi.org/10.1002/advs.202306486

3. Leung AOW, Poon ACH, Wang X, Feng C, Chen PK, Zheng ZF, To MKT, Chan WCW, Cheung M, Chan D. Suppression of apoptosis impairs phalangeal joint formation in the pathogenesis of brachydactyly type A1. (2024) Nature Commun 15 (1): 2229 https://doi.org/10.1038/s41467-024-45053-0

4. Chen YL, Feng XL, Tam KW, Cheung MPL, Chan KKK, Shum DKY, Cheung CW, Chan YS, Cheung M and Liu JA.  Intrinsic and extrinsic actions of human neural progenitors with SUFU inhibition promote tissue repair and functional recovery from severe spinal cord injury. (2024) NPJ Regenerative Med 9 (1): 13 https://doi.org/doi:%2010.1038/s41536-024-00352-4

5. Yu Jing, Wong S, Lin ZN, Shan ZM, Fan CY, Xia ZY, Cheung M, Zhu X, Liu JA, Cheung CW. High-frequency spinal stimulation suppresses microglial Kaiso-P2X7R axis-induced inflammation to alleviate neuropathic pain in rats. (2024) Annals of Neurology  https://doi.org/10.1002/ana.26898

6. Liu JA*, Tam KW, Chen YL, Feng XL, Chan CWL, Lo ALH, Wu KLK, Hui M-N, Wu M-H, Chan KKK, Cheung MPL, Cheung CW, Shum DKY, Chan YS and Cheung M*. Transplanting human neural stem cells with approximately 50% reduction of SOX9 gene dosage promotes tissue repair and functional recovery from severe spinal cord injury. (2023) Adv Sci (Weinh); e2205804 https://doi.org/10.1002/advs.202205804.
7. Hu F, Fong KO, Cheung MPL, Liu JA, Liang R, Li TW, Sharma R, IP PPC, Yang XT and Cheung M*. DEPDC1B promotes melanoma angiogenesis and metastasis through sequestration of ubiquitin ligase CDC16 to stabilize secreted SCUBE3. (2022) Adv Sci 2105226, https://doi.org/10.1002/advs.202105226.
8. Guo D, Wang Y, Cheng Y, Liao S, Hu J, Du F, Xu G, Liu Yq, Cai KQ, Cheung M, Wainwright B, Lu Q, Zhao Y and Yang ZJ. Tumor cells generate astrocyte-like cells that contribute to SHH-driven medulloblastoma relapse. (2021) J Exp Med 218 (9): e20202350.
9. Yang XT, Hu F, Liu JA, Yu Shan, Cheung MPL, Liu XL, Ng IOL, Guan XY, Wong KKW, Sharma R, Lung HL, Jiao YF, Lee LT and Cheung M*. Nuclear DLC1 exerts oncogenic function through association with FOXK1 for cooperative activation of MMP9 expression in melanoma. (2020) Oncogene https://www.nature.com/articles/s41388-020-1274-8.
   Behind the paper: https://cancercommunity.nature.com/channels/465-behind-the-paper/posts/64108-dlc1-is-oncogenic-in-melanoma
10. Liu JA, Tai A, Hong JL, Cheung MPL, Sham MH, Cheah KSE, Cheung CW and Cheung M*. Fbxo9 functions downstream of Sox10 to determine neuron-glial fate choice in the dorsal root ganglia through Neurog2 destabilization. (2020) Proc Natl Acad Sci USA 117(8): 4199-421, https://www.pnas.org/content/early/2020/02/05/1916164117.
    Press release: HKUMed discovers new molecular mechanism in determining sensory neuron which paves the way for new therapeutic opportunities
11. Wu Z, Rao Y, Zhang S, Kim EJ, Oki S, Harada H, Cheung M and Jung HS. Cis-control of Six1 expression in neural crest cells during craniofacial development. (2019) Dev Dyn 248 (12): 1264-1272.
12. Yang XT, Liang R, Liu CX, Liu JA, Cheung MPL, Liu XL, Man OY, Guan XY, Lung HL and Cheung M*. Sox9 is a dose-dependent metastatic fate determinant in melanoma. (2019) Journal of Experimental and Clinical Cancer Research 38: 17, https://doi.org/10.1186/s13046-018-0998-6.
13. Wang YX, Liu JA, Leung KK, Sham MH, Chan D, Cheah KSE and Cheung M*. Reprogramming of mouse calvarial osteoblasts into induced pluripotent stem cells. (2018) Stem Cells International Article ID 5280793, https://doi.org/10.1155/2018/5280793.
14. Liu JA, Rao YX, Cheung MPL, Hui MN, Wu M-H, Chan LK, Ng IOL, Niu B, Cheah KSE, Sharma R, Hodgson L and Cheung M*. Asymmetric localisation of DLC1 defines avian trunk neural crest polarity for directional delamination and migration. (2017) Nature Commun 8(1): 1185, https://doi.org/10.1038/s41467-017-01107-0.
    (Press release in the Faculty homepage: https://www.med.hku.hk/news/press/2017/11)
15. Wang YX, Wu MH, Cheung MPL, Sham MH, Akiyama H, Chan D, Cheah KSE and Cheung M*. Reprogramming of dermal fibroblasts into osteo-chondrogenic cells with elevated osteogenic potency by defined transcription factors. (2017) Stem Cell Reports 8(6): 1587-1599. 
16. Carrasco-Garcia E, Lopez L, Aldaz P, Arevalo S, Aldaregia J, Egana L, Bujanda L, Cheung M, Sampron N, Garcia I and Matheu A. SOX9-regulated cell plasticity in colorectal metastasis is attenuated by rapamycin. (2016) Sci Rep 6:32350.
17. Kam MKM, Cheung M, Zhu JJ, Cheng WWC, Sat EWY, Tam PKH and Lui VCH. Perturbation of Hoxb5 signaling in vagal and trunk neural crest cells causes apoptosis and neurocristopathies in mice. (2014) Cell Death & Differentiation 21: 278-289.
18. Liu JA, Wu MH, Yan CH, Chau BK, So H, Ng A, Chan A, Cheah KS, Briscoe J and Cheung M*. Phosphorylation of Sox9 is required for neural crest delamination and is required downstream of BMP and canonical Wnt singlaing. (2013) Proc Natl Acad Sci USA 110 (8): 2882-2887.

(*Corresponding author)

Review articles:

1. Tianyuan S and Cheung M*. Urine-derived pluripotent/neural stem cells for modeling neurological diseases. (2021) Cell & Bioscience 11(1): 85, https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-021-00594-5.
2. Cheung M, Tai A, Lu J and Cheah KSE. Acquisition of multipotent and migratory neural crest cells in vertebrate evolution. (2019) Current Opinion in Genetics & Research 57: 84-90, https://doi.org/10.1016/j.gde.2019.07.018.
3. Liu JA and Cheung M*. Neural crest stem cells and their therapeutic applications. (2016) Dev Biol 419 (2): 199-216. (Highlighted article in the journal homepage) https://www.journals.elsevier.com/developmental-biology/highlighted-articles/db-ecr-mcheung
4. Tsang KY, Cheung M, Chan D and Cheah KSE. The developmental roles of the extracellular matrix: beyond structure to regulation. (2010) Cell and tissue research 339 (1): 93-110.

(*Corresponding author)

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    第一節 / 第二節 / 第三節

• Research Impact Fund (PC: 2023/24)
• Seed Fund for Collaborative Project (2022/2023)
• NSFC General Program (PI: 2020-2023)
• Liu Po Shan/Dr Vincent Liu Endowment Fund for Motor Neurone Disease (2018-2019, 2021-2022 and 2024-2025)
• HMRF (PI: 2018, 2019)
• RGC General Research Fund (PI: 2010, 2015, 2016, 2017, 2019, 2020, 2021, 2022, 2025)
• Hong Kong Scotland Collaborative Research Scholarship (PI: 2014)
• RGC Early Career Scheme (PI: 2014)
• Theme-based Research Scheme (Co-I: 2014-2019)

• Seed Funding for Basic Research (PI: 2008, 2012, 2014-2022)

• Faculty Outstanding Research Output Award 2018 (in the capacity of corresponding author), The University of Hong Kong
• Research Output Prize 2010 (in the capacity of co-author), The University of Hong Kong

• Mr Lo Lok Hang Amos (Technical Officer)
• Dr. Tianyuan Shi (CURE SMA Postdoctoral Fellow)
• Dr. Lin Shuling (HKU-SZ Hospital, Postdoctoral Fellow)
• Ms Jia Ying Ng (PhD student, 2021 - )
• Mr Dennis Pang (HKU Presidential PhD Scholarship, PhD student, 2022 - )
• Mr Darsh Arvindbhai Vaghani (PhD student, 2022- )
• Mr Bowen Fu (PhD student, 2024 - )
• Ms Haylee Tam (MPhil student, 2024 - )
• Ms Shek Hiu Tung (MPhil student, 2024 -  )
• Ms Jessica Lu (HKPF/HKPS awardee, PhD student, 2024 - )
• Ms Qianlin Zhuo (HKU Presidential PhD Scholarship, PhD student, 2025 - )
• Mr Park Yeh John (MBBS yr 4, Master of Medical Research)
• Ms Jasmine Chae (MBBS yr 4, Master of Medical Research)
• Mr Jarick Wang (MMedSc student)
• Mr Wong Chi Lok (Anson) (Research Assistant)
• Ms Venus Ho (Research Assistant)
• Mr Anthony Choi (BSc in Biochemistry, yr 4, Final Year Project)
• Ms Zoe Tung Yuk Zhang (BSc, yr 4, Final Year Project)

Hong Kong Society for Developmental Biology